(RS)-3,5-DHPG

Names

[ CAS No. ]:
146255-66-5

[ Name ]:
(RS)-3,5-DHPG

[Synonym ]:
(RS)-3,5-DHPG
tert-Butylisopentanal
HEXANAL,3,5,5-TRIMETHYL
Isononylaldehyde
3,5,5-Trimethylcapronaldehyde
3,5,5,-trimethylhexanal
Hexanal,3,5,5-trimethl

Biological Activity

[Description]:

DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D[2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

[Target]

mGluR 1

mGluR 5


[References]

[1]. Winder DG, et al. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9.

[2]. Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43.

Chemical & Physical Properties

[ Density]:
1.55g/cm3

[ Boiling Point ]:
448.8ºC at 760mmHg

[ Molecular Formula ]:
C8H9NO4

[ Molecular Weight ]:
183.16100

[ Flash Point ]:
225.2ºC

[ Exact Mass ]:
183.05300

[ PSA ]:
103.78000

[ LogP ]:
0.88250

Related Compounds