PROTAC FKBP Degrader-3

Names

[ CAS No. ]:
2079056-43-0

[ Name ]:
PROTAC FKBP Degrader-3

Biological Activity

[Description]:

PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

[Target]

VHL

FKBP

[In Vitro]

PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated[1].

[References]

[1]. Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₈H₉₀N₆O₁₇S

[ Molecular Weight ]:
1295.54

[ Storage condition ]:
-20°C

PROTAC FKBP Degrader-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds