GLL398

Names

[ CAS No. ]:
2077980-80-2

[ Name ]:
GLL398

Biological Activity

[Description]:

GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cancer

[In Vitro]

GLL398 is a boron-modified GW5638 analog[1].

[References]

[1]. Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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