Mal-amido-(CH2COOH)2

Names

[ CAS No. ]:
207613-14-7

[ Name ]:
Mal-amido-(CH2COOH)2

Biological Activity

[Description]:

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].

[In Vivo]

ADC Linker

[References]

[1]. Dubowchik GM, et al. Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages.Bioorg Med Chem Lett. 2002 Jun 3;12(11):1529-32.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₂N₂O₇

[ Molecular Weight ]:
284.22

Mal-amido-(CH2COOH)2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds