ISO-PPADS TETRASODIUM SALT

Names

[ CAS No. ]:
207572-67-6

[ Name ]:
ISO-PPADS TETRASODIUM SALT

[Synonym ]:
1,4-Benzenedisulfonic acid, 2-[(E)-2-[4-formyl-5-hydroxy-6-methyl-3-(2-phosphonoethyl)-2-pyridinyl]diazenyl]-, sodium salt (1:2)
Disodium (2-{2-[(E)-(2,5-disulfophenyl)diazenyl]-4-formyl-5-hydroxy-6-methyl-3-pyridinyl}ethyl)phosphonate

Biological Activity

[Description]:

Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI)[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[Target]

43 nM and 84 nM (P2X1 and P2X3 receptor)[2]

[References]

[1]. González-López A, et al. Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury. Crit Care Med. 2019 Nov;47(11):e911-e918.

[2]. Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₀N₃Na₄O₁₂PS₂

[ Molecular Weight ]:
599.30

[ Exact Mass ]:
552.960266

Related Compounds

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