207572-67-6

207572-67-6 structure

Name: ISO-PPADS TETRASODIUM SALT
Chemical Name: Disodium (2-{2-[(E)-(2,5-disulfophenyl)diazenyl]-4-formyl-5-hydroxy-6-methyl-3-pyridinyl}ethyl)phosphonate
CAS Number: 207572-67-6
Molecular Formula: C₁₄H₁₀N₃Na₄O₁₂PS₂
Molecular Weight: 599.30
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
Create Date: 2018-06-05 11:36:56
Modify Date: 2025-08-25 01:37:19
Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI)[1][2].

Name	Disodium (2-{2-[(E)-(2,5-disulfophenyl)diazenyl]-4-formyl-5-hydroxy-6-methyl-3-pyridinyl}ethyl)phosphonate
Synonyms	1,4-Benzenedisulfonic acid, 2-[(E)-2-[4-formyl-5-hydroxy-6-methyl-3-(2-phosphonoethyl)-2-pyridinyl]diazenyl]-, sodium salt (1:2) Disodium (2-{2-[(E)-(2,5-disulfophenyl)diazenyl]-4-formyl-5-hydroxy-6-methyl-3-pyridinyl}ethyl)phosphonate

Description	Iso-PPADS tetrasodium is a P2X-purinoceptor antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC50s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI)[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Target	43 nM and 84 nM (P2X1 and P2X3 receptor)[2]
References	[1]. González-López A, et al. Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury. Crit Care Med. 2019 Nov;47(11):e911-e918. [2]. Brown SG, et al. Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors. Drug Dev Res. 2001 Aug;53(4):281-291.