1-naphthol-d8

Names

[ CAS No. ]:
207569-03-7

[ Name ]:
1-naphthol-d8

Biological Activity

[Description]:

1-Naphthol-d8 is the deuterium labeled 1-Naphthol[1]. 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Swain J, et al. 1-Naphthol as an ESPT fluorescent molecular probe for sensing thermotropic microenvironmental changes of pluronic F127 in aqueous media. Phys Chem Chem Phys. 2015 Jul 14;17(26):16752-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10D8O

[ Molecular Weight ]:
152.21900

[ Exact Mass ]:
152.10800

[ PSA ]:
20.23000

[ LogP ]:
2.54540

Related Compounds