PF-CBP1 hydrochloride
Names
[ CAS No. ]:
2070014-93-4
[ Name ]:
PF-CBP1 hydrochloride
[Synonym ]:
4-(2-(5-(3,5-Dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine hydrochloride
Biological Activity
[Description]:
PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain.Target: CREBin vitro: PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors. [1]
[Related Catalog]:
[References]
[Related Small Molecules]
(+)-JQ1
|
GSK126
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Tazemetostat (EPZ-6438)
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Birabresib (OTX015)
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A 485
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Curcumin
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ARV-771
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ARV-825
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I-BET762
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BI 2536
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GSK343
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C646
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3-Deazaneplanocin A (hydrochloride)
|
I-BET151
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666-15
Chemical & Physical Properties
[ Molecular Formula ]:
C29H36N4O3·HCl
[ Molecular Weight ]:
525.08
[ Storage condition ]:
-20℃