JAK-IN-34

Names

[ CAS No. ]:
2068766-90-3

[ Name ]:
JAK-IN-34

Biological Activity

[Description]:

JAK-IN-34 (compound 11n) is a potent against of JAKs with IC50 values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

JAK1:0.40 nM (IC50)

JAK2:0.83 nM (IC50)

JAK3:2.10 nM (IC50)

Tyk2:1.95 nM (IC50)

[References]

[1]. Jinbao Xiang, et al. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors. Bioorg Chem. 2023.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆N₆O

[ Molecular Weight ]:
450.53

Related Compounds

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