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2068766-90-3

2068766-90-3 structure

2068766-90-3 structure

Name: JAK-IN-34
Chemical Name: JAK-IN-34
CAS Number: 2068766-90-3
Molecular Formula: C₂₇H₂₆N₆O
Molecular Weight: 450.53
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2024-01-13 14:03:08
Modify Date: 2024-01-13 14:03:08
JAK-IN-34 (compound 11n) is a potent against of JAKs with IC50 values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety[1].

Name	JAK-IN-34

Description	JAK-IN-34 (compound 11n) is a potent against of JAKs with IC50 values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:0.40 nM (IC50) JAK2:0.83 nM (IC50) JAK3:2.10 nM (IC50) Tyk2:1.95 nM (IC50)
References	[1]. Jinbao Xiang, et al. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors. Bioorg Chem. 2023.

Molecular Formula	C₂₇H₂₆N₆O
Molecular Weight	450.53