S18-000003

Names

[ CAS No. ]:
2068119-11-7

[ Name ]:
S18-000003

Biological Activity

[Description]:

S18-000003 is a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor with an IC50 of 29 nM. S18-000003 inhibits IL-17 production[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

[Target]

IC50: 29 nM (RORγt)[1]

[References]

[1]. Sasaki Y, et al. Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅F₃N₂O₄S

[ Molecular Weight ]:
518.55

Related Compounds

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