Asundexian

Names

[ CAS No. ]:
2064121-65-7

[ Name ]:
Asundexian

Biological Activity

[Description]:

Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[In Vivo]

Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model[1].

[References]

[1]. Thomas D, et al. First evaluation of the safety, pharmacokinetics, and pharmacodynamics of BAY 2433334, a small molecule targeting coagulation factor XIa. J Thromb Haemost. 2021;19(10):2407-2416.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₁ClF₄N₆O₄

[ Molecular Weight ]:
592.93

Related Compounds

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