L-R4W2

Names

[ CAS No. ]:
206350-79-0

[ Name ]:
L-R4W2

[Synonym ]:
MFCD03791319

Biological Activity

[Description]:

L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 may act as a potent analgesic[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[Target]

TRPV1:0.1 μM (IC50)

[References]

[1]. Planells-Cases R, et, al. Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 2000 Sep 15; 481(2): 131-6.

[2]. Himmel HM, et, al. The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 2002 Jun; 301(3): 981-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₆H₇₁N₂₁O₆

[ Molecular Weight ]:
1015.18000

[ Exact Mass ]:
1014.57000

[ PSA ]:
488.00000

[ LogP ]:
4.74190

Related Compounds

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