PROTAC Linker 9

Names

[ CAS No. ]:
206265-94-3

[ Name ]:
PROTAC Linker 9

[Synonym ]:
t-Butyl-N-(2-{2-[2-(tosyloxy)-ethoxy]-ethoxy}-ethyl)-carbamate

Biological Activity

[Description]:

PROTAC Linker 9 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 9 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₉NO₇S

[ Molecular Weight ]:
403.49000

[ Exact Mass ]:
403.16600

[ PSA ]:
108.54000

[ LogP ]:
3.72990

Related Compounds

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