2'-O,4'-C-Methylenecytidine

Names

[ CAS No. ]:
206055-69-8

[ Name ]:
2'-O,4'-C-Methylenecytidine

Biological Activity

[Description]:

2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. bicyclic nucleoside analogue, N-type conformation, synthesize oligonucleotides, duplexes

[2]. Obika S, et, al. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Letters. 1998 Jul 23; 39(30):5401-04.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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