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k-ras(g12c) inhibitor 6

Names

[ CAS No. ]:
2060530-16-5

[ Name ]:
k-ras(g12c) inhibitor 6

[Synonym ]:
MFCD28099807
Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-
N-{1-[(2,4-Dichlorophenoxy)acetyl]-4-piperidinyl}-4-sulfanylbutanamide
N-{1-[(2,4-Dichlorophenoxy)acetyl]piperidin-4-Yl}-4-Sulfanylbutanamide

Biological Activity

[Description]:

K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

K-Ras(G12C)


[References]

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
643.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H22Cl2N2O3S

[ Molecular Weight ]:
405.33918

[ Flash Point ]:
342.9±31.5 °C

[ Exact Mass ]:
404.072815

[ LogP ]:
2.49

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.594

[ Storage condition ]:
-20℃

Related Compounds