IMP-1088

Names

[ CAS No. ]:
2059148-82-0

[ Name ]:
IMP-1088

[Synonym ]:
1H-Indazole-3-methanamine, 5-[3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl]-N,N,1-trimethyl-
1-(5-{3,4-Difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine

Biological Activity

[Description]:

IMP-1088 is a potent, selective human N-myristoyltransferase with IC50 of less than 1 nM for both HsNMT1 and HsNMT2, inhibits Rhinoviruses (RVs) capsid myristoylation in cells; pharmacological and rapidly inhibits host-cell N-myristoylation, potently and efficiently block RV replication (IC50=17 nM) without cytotoxicity; potently blocks a key step in viral capsid assembly, to deliver a low nanomolar antiviral activity against multiple RV strains, poliovirus and foot and-mouth disease virus, and protection of cells against virus-induced killing.

[References]

References 1. Aurélie Mousnier, et al. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nature Chemistry (2018). doi:10.1038/s41557-018-0039-2. View Related Products by Target Rhinovirus

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
566.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₂₉F₂N₅O

[ Molecular Weight ]:
453.527

[ Flash Point ]:
296.6±30.1 °C

[ Exact Mass ]:
453.234009

[ LogP ]:
3.73

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.595

Related Compounds

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