Benzylhydrazine dihydrochloride
Names
[ CAS No. ]:
20570-96-1
[ Name ]:
Benzylhydrazine dihydrochloride
[Synonym ]:
EINECS 243-887-1
BENZYL HYDRAZINE di HCl
Benzylhydrazine dihydrochloride
1-benzylhydrazine dihydrochloride
Hydrazine,benzyl-,dihydrochloride
Hydrazine, (phenylmethyl)-, hydrochloride (1:2)
BnNHNH2*2HCl
N-benzylhydrazine dihydrochloride
(phenylmethyl)hydrazine dihydrochloride
benzylhydrazine*2HCl
MFCD00012921
Benzyl-hydrazine dihydrochloride
benzylhydrazine dihydrogen chloride
Chemical & Physical Properties
[ Density]:
1.033g/cm3
[ Boiling Point ]:
265.4ºC at 760 mmHg
[ Melting Point ]:
143-145 °C (dec.)(lit.)
[ Molecular Formula ]:
C7H12Cl2N2
[ Molecular Weight ]:
195.090
[ Flash Point ]:
132ºC
[ Exact Mass ]:
194.037750
[ PSA ]:
38.05000
[ LogP ]:
3.34510
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MU8540000
- CHEMICAL NAME :
- Hydrazine, benzyl-, dihydrochloride
- CAS REGISTRY NUMBER :
- 20570-96-1
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C7-H10-N2.2Cl-H
- MOLECULAR WEIGHT :
- 195.11
- WISWESSER LINE NOTATION :
- ZM1R &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - antipsychotic
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 gm/kg/29W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Bacteria - Bacillus subtilis
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 5,343,1968
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
MU8540000
[ Hazard Class ]:
6.1
[ HS Code ]:
2928000090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Preparation
Customs
[ HS Code ]: 2928000090
[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%
Articles
J. Pharm. Sci. 74(1) , 105-7, (1985)
A GC procedure for the simultaneous determination of hydrazine and benzylhydrazine in isocarboxazid raw material and tablet formulations has been developed. The method is based on the reaction of benz...
Benzylhydrazine as a pseudo-substrate of bovine serum amine oxidase.Biochem. J. 260(1) , 19-25, (1989)
Bovine serum amine oxidase is inhibited by benzylhydrazine (BHy), but recovers full activity after a few hours incubation [Hucko-Haas & Reed (1970) Biochem. Biophys. Res. Commun. 38, 396-400]. The fir...
Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay.Bioorg. Med. Chem. 12(13) , 3649-55, (2004)
A series of indole-2-carboxylic acid benzylidene-hydrazides has been identified as a new class of potent apoptosis inducers through a novel cell-based caspase HTS assay. The screening hit, 5-chloro-3-...