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SHP394

Names

[ CAS No. ]:
2055757-40-7

[ Name ]:
SHP394

Biological Activity

[Description]:

SHP394 is an orally efficacious protein tyrosine phosphatase SHP2 inhibitor with an IC50 of 23 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[Target]

IC50: 23 nM (SHP2)[1]


[References]

[1]. Sarver P, et al. 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. J Med Chem. 2019 Feb 28;62(4):1793-1802.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H25F3N6O2S

[ Molecular Weight ]:
470.51