Cedirogant

Names

[ CAS No. ]:
2055496-11-0

[ Name ]:
Cedirogant

Biological Activity

[Description]:

Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant can be used for psoriasis research[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR

Research Areas >> Inflammation/Immunology

[Target]

RORγt[1]

[In Vitro]

The transcription factor retinoic acid-related orphan receptor gamma t (RORγt) has been identified as the master regulator of TH17 cell differentiation and IL-17/22 production and is therefore an attractive target for the treatment of inflammatory diseases. Cedirogant (ABBV-157) has the potential for chronic plaque psoriasis research[1].

[References]

[1]. Elena Campione, et al. Experimental Pharmacological Management of Psoriasis. J Exp Pharmacol. 2021 Jul 26;13:725-737.

[2]. Christian Gege. Retinoic acid-related orphan receptor gamma t (RORγt) inverse agonists/antagonists for the treatment of inflammatory diseases - where are we presently? Expert Opin Drug Discov. 2021 Jul 7;1-19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₀Cl₃F₃N₂O₃

[ Molecular Weight ]:
547.78

Cedirogant

Names

Biological Activity

Chemical & Physical Properties

Related Compounds