LM2I

Names

[ CAS No. ]:
2055494-50-1

[ Name ]:
LM2I

Biological Activity

[Description]:

LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Argininosuccinate synthetase (ASS1)[1]

[References]

[1]. Peng K, et al. Spinosyn A and Its Derivative Inhibit Colorectal Cancer Cell Growth via the EGFR Pathway. J Nat Prod. 2023 Sep 8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₇₇N₃O₁₁

[ Molecular Weight ]:
860.13

Related Compounds

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