PF-06678419
Names
[ CAS No. ]:
2055468-48-7
[ Name ]:
PF-06678419
Biological Activity
[Description]:
PF-06678419 (PF06678419) is a potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.44 uM; displays relatively selectivity over NaDC1 and NaDC3 (7-10-fold).
[References]
References 1. Pajor AM, et al. Mol Pharmacol. 2016 Dec;90(6):755-765. 2. Huard K, et al. Sci Rep. 2015 Dec 1;5:17391. View Related Products by Target Sodium-coupled Citrate Transporter (NaCT,SLC13A5)
Chemical & Physical Properties
[ Molecular Formula ]:
C12H13IO5
[ Molecular Weight ]:
364.135