MNK8

Names

[ CAS No. ]:
2055078-49-2

[ Name ]:
MNK8

Biological Activity

[Description]:

MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Signaling Pathways >> Stem Cell/Wnt >> STAT

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Survivin

Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

STAT3

Bcl-2

[In Vitro]

MNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1[1].

[References]

[1]. Sajith AM, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₂N₂O₂

[ Molecular Weight ]:
252.27

Related Compounds

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