2055078-49-2

2055078-49-2 structure

Name: MNK8
Chemical Name: MNK8
CAS Number: 2055078-49-2
Molecular Formula: C₁₅H₁₂N₂O₂
Molecular Weight: 252.27
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-25 08:16:28
Modify Date: 2024-01-13 11:07:10
MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].

Name	MNK8

Description	MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Survivin Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	STAT3 Bcl-2
In Vitro	MNK8 (50 μM, 0-48 h) increases Sub-G1 cells in a time-dependent fashion, and decreases the expression of antiapoptotic proteins such as Bcl-2, survivin, and cyclin D1[1].
References	[1]. Sajith AM, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332.

Molecular Formula	C₁₅H₁₂N₂O₂
Molecular Weight	252.27