t-Boc-N-amido-PEG5-NHS ester

Names

[ CAS No. ]:
2055040-78-1

[ Name ]:
t-Boc-N-amido-PEG5-NHS ester

[Synonym ]:
MFCD29764335

Biological Activity

[Description]:

Boc-N-PEG5-C2-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₈N₂O₁₁

[ Molecular Weight ]:
506.54

[ Storage condition ]:
2-8°C

t-Boc-N-amido-PEG5-NHS ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds