JS-K

Names

[ CAS No. ]:
205432-12-8

[ Name ]:
JS-K

[Synonym ]:
HMS3261L12
O2-(2,4-Dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate
JS-K

Biological Activity

[Description]:

JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH[1]. JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[References]

[1]. Shami PJ, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther. 2003 Apr;2(4):409-17.

Chemical & Physical Properties

[ Density]:
1.606g/cm3

[ Boiling Point ]:
546.692ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₆N₆O₈

[ Molecular Weight ]:
384.30200

[ Flash Point ]:
284.429ºC

[ Exact Mass ]:
384.10300

[ PSA ]:
174.76000

[ LogP ]:
2.89380

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.656

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TL1364200

Precursor & DownStream

Precursor

DownStream

Articles

N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia.

Macromol. Biosci. 16 , 121-8, (2016)

There is a need for new treatment strategies of acute myeloid leukemia (AML). In this study, four different drugs, including cytarabine, daunorubicin, GDC-0980, and JS-K, were investigated in vitro fo...

Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.

Redox Biol. 1 , 115-24, (2013)

JS-K is a nitric oxide (NO)-releasing prodrug of the O (2)-arylated diazeniumdiolate family that has demonstrated pronounced cytotoxicity and antitumor properties in a variety of cancer models both in...

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells.

BMC Cancer 12 , 130, (2012)

Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In conseq...

Related Compounds

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