2-(6-aminopurin-9-yl)-5-methylidene-oxolane-3,4-diol

Names

[ CAS No. ]:
20535-04-0

[ Name ]:
2-(6-aminopurin-9-yl)-5-methylidene-oxolane-3,4-diol

[Synonym ]:
4',5'-didehydroadenosine
4',5'-didehydro-5'-deoxyadenosine

Biological Activity

[Description]:

4′,5′-Didehydro-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.91g/cm3

[ Boiling Point ]:
591.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₁N₅O₃

[ Molecular Weight ]:
249.23

[ Flash Point ]:
311.3ºC

[ Exact Mass ]:
249.08600

[ PSA ]:
119.31000

[ Vapour Pressure ]:
8.14E-15mmHg at 25°C

[ Index of Refraction ]:
1.867

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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