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2'-MeCCPA

Names

[ CAS No. ]:
205171-12-6

[ Name ]:
2'-MeCCPA

[Synonym ]:
HMS3268H12
2'-IODO-2-PHENYLACETOPHENONE
2-chloro-2'-C-methyl-N6-cyclopentyl-adenosine

Biological Activity

[Description]:

2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs)[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

A1AR


[In Vivo]

2’-MeCCPA (1 nM-1 M) at reperfusion significantly reduces infarct size to risk ratio in male Sprague-Dawley rats[1].

[References]

[1]. J Bhandal, et al. Adenosine a1 receptor activation can protect the myocardium from ischaemia reperfusion injury post reperfusion. BMJ Journals. Volume 104, Issue Suppl 3.

[2]. Muntean BS, et al. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22(1):255-268.

Chemical & Physical Properties

[ Density]:
1.76g/cm3

[ Boiling Point ]:
643.3ºC at 760 mmHg

[ Molecular Formula ]:
C16H22ClN5O4

[ Molecular Weight ]:
383.83000

[ Flash Point ]:
342.9ºC

[ Exact Mass ]:
383.13600

[ PSA ]:
114.55000

[ LogP ]:
1.17280

[ Vapour Pressure ]:
1.98E-17mmHg at 25°C

[ Index of Refraction ]:
1.777

Related Compounds