FL-18
Names
[ CAS No. ]:
2051196-02-0
[ Name ]:
FL-18
Biological Activity
[Description]:
FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.FL-18 showed better inhibition potency than NMS-873, a well-known p97 inhibitor.FL-18 covalently modified C522 residue in p97 and showed potent enzymatic inhibition.FL-18 showed potent inhibition towards U87MG glioma cancer cells (IC50=31 nM).FL-18 inhibited the p97 activity and induced aggregation of ubiquitinated proteins in U87MG cells.
[References]
1. Zi Ye, et al. Acta Pharm Sin B. 2022 Feb;12(2):982-989.
Chemical & Physical Properties
[ Molecular Formula ]:
C22H21N3O3
[ Molecular Weight ]:
375.428
Related Compounds
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.