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HDAC3 Inhibitor (Histone Deacetylase 3)

Names

[ CAS No. ]:
2044701-99-5

[ Name ]:
HDAC3 Inhibitor (Histone Deacetylase 3)

Biological Activity

[Description]:

HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC3:5.96 ± 0.0 nM (IC50)

HDAC1:36.4 ± 0.2 nM (IC50)

HDAC2:89.9 ± 0.7 nM (IC50)


[References]

[1]. Moreno-Yruela C, Olsen CA. Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity. ACS Med Chem Lett. 2022 Mar 16;13(5):779-785.

Chemical & Physical Properties

[ Density]:
1.140±0.06 g/cm3(Predicted)

[ Boiling Point ]:
562.5±50.0 °C(Predicted)

[ Molecular Formula ]:
C20H23N3O2

[ Molecular Weight ]:
337.42


Related Compounds