Mcl1-IN-12

Names

[ CAS No. ]:
2042211-12-9

[ Name ]:
Mcl1-IN-12

Biological Activity

[Description]:

Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Ki: 0.29 (Mcl-1), 3.1 μM (Bcl-2)[1]


[References]

[1]. Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211.

Chemical & Physical Properties

[ Molecular Formula ]:
C45H46N4O6S2

[ Molecular Weight ]:
803.00

Related Compounds