Mcl1-IN-2

Names

[ CAS No. ]:
292057-76-2

[ Name ]:
Mcl1-IN-2

[Synonym ]:
7-[(2-Pyridinylamino)(2-thienyl)methyl]-8-quinolinol
8-Quinolinol, 7-[(2-pyridinylamino)-2-thienylmethyl]-
7-[(Pyridin-2-ylamino)(2-thienyl)methyl]quinolin-8-ol
MFCD01466199

Biological Activity

[Description]:

Mcl1-IN-2 is an inhibitor of myeloid cell factor 1 (Mcl-1).

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Mcl-1

[In Vitro]

Mcl1-IN-2 (Compound 2) is a Mcl-1 inhibitor, though without a reported IC50 value[1].

[References]

[1]. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.

[Related Small Molecules]

Venetoclax (ABT-199) | ABT-263 | S63845 | ABT-737 | Obatoclax Mesylate | A-1210477 | A-1155463 | WEHI-539 hydrochloride | A-1331852 | Bax inhibitor peptide V5 | FX 1 | Gambogic Acid | TW-37 | UMI-77 | Acetate gossypol

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
557.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₅N₃OS

[ Molecular Weight ]:
333.407

[ Flash Point ]:
290.9±28.7 °C

[ Exact Mass ]:
333.093567

[ LogP ]:
3.42

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.755

[ Storage condition ]:
2-8℃

Related Compounds

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