PF-4363467
Names
[ CAS No. ]:
2040055-84-1
[ Name ]:
PF-4363467
Biological Activity
[Description]:
PF-4363467 (PF 04363467) is a novel highly potent, brain penetrant dopamine D3/D2 receptor antagonist with Ki of 1.3/692 nM respectively, with high selectivity for D3R versus other biogenic amine receptors; dose-dependently attenuated opioid self-administration and opioid drug-seeking behavior in a rat operant reinstatement model using animals trained to self-administer fentanyl.
[References]
References 1. Wager TT, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):165-177. View Related Products by Target Dopamine Receptor
Chemical & Physical Properties
[ Molecular Formula ]:
C22H30N2O3S
[ Molecular Weight ]:
402.553
Related Compounds
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