JNJ 55511118

Names

[ CAS No. ]:
2036081-86-2

[ Name ]:
JNJ 55511118

[Synonym ]:
2H-Benzimidazol-2-one, 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-
5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one

Biological Activity

[Description]:

JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2; demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration, exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo.

[References]

References 1. Maher MP, et al. J Pharmacol Exp Ther. 2016 May;357(2):394-414. 2. Ravula S, et al. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. View Related Products by Target iGluR

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
279.7±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₈ClF₃N₂O₂

[ Molecular Weight ]:
328.674

[ Flash Point ]:
123.0±27.3 °C

[ Exact Mass ]:
328.022644

[ LogP ]:
4.29

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.560

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.