CDK4/6-IN-17

Names

[ CAS No. ]:
2035069-96-4

[ Name ]:
CDK4/6-IN-17

Biological Activity

[Description]:

CDK4/6-IN-17 (compound 12) is an orally active CDK4/6 inhibitor with IC50 ranging of 10-100 nM in BE(2) cells. CDK4/6-IN-17 inhibits tumor growth in COLO205 xenograft model[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4/6


[References]

[1]. Zhao X, et al. Preparation of benzopyrroloimidazolyl compounds as CDK4/6 kinase inhibitors. World Intellectual Property Organization, WO2016173505 A1. 2016-11-03.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H28F4N8

[ Molecular Weight ]:
540.56

Related Compounds