Rbin-2

Names

[ CAS No. ]:
2032282-97-4

[ Name ]:
Rbin-2

[Synonym ]:
7-Bromo-2-(2-methyl-allylsulfanyl)-9H-1,3,4,9-tetraaza-fluorene
5H-1,2,4-Triazino[5,6-b]indole, 7-bromo-3-[(2-methyl-2-propen-1-yl)thio]-
Rbin-2
7-Bromo-3-[(2-methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
7-Bromo-3-[(2-methyl-2-propen-1-yl)thio]-5H-1,2,4-Triazino[5,6-b]indole

Biological Activity

[Description]:

Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Others

[References]

[1]. Kawashima SA, et al. Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell. 2016 Oct 6;167(2):512-524.e14.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
524.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₁BrN₄S

[ Molecular Weight ]:
335.22

[ Flash Point ]:
270.9±32.9 °C

[ Exact Mass ]:
333.988770

[ LogP ]:
4.05

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.750

Related Compounds

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