M-6-G TRIFLUOROACETATE-HYDRATE

Names

[ CAS No. ]:
20290-10-2

[ Name ]:
M-6-G TRIFLUOROACETATE-HYDRATE

[Synonym ]:
Morphine glucuronide

Chemical & Physical Properties

[ Density]:
1.64g/cm3

[ Boiling Point ]:
731.6ºC at 760mmHg

[ Melting Point ]:
237-240°C (dec.)

[ Molecular Formula ]:
C₂₃H₂₇NO₉

[ Molecular Weight ]:
461.46200

[ Flash Point ]:
396.3ºC

[ Exact Mass ]:
461.16900

[ PSA ]:
149.15000

[ Vapour Pressure ]:
1.8E-22mmHg at 25°C

[ Index of Refraction ]:
1.731

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ6500700

CHEMICAL NAME :: Glucopyranosiduronic acid, 7,8-didehydro-4,5-alpha-epoxy-3-hydroxy-17-methylmorp hinan-6- alpha-yl-, beta-D-

CAS REGISTRY NUMBER :: 20290-10-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H27-N-O9

MOLECULAR WEIGHT :: 461.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 432 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 67(4),97P,1971

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H317-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-43

[ Safety Phrases ]:
36

[ RIDADR ]:
UN 1993C 3 / PGIII

[ WGK Germany ]:
3

[ RTECS ]:
LZ6500700

Articles

Morphine glucuronidation increases its analgesic effect in guinea pigs.

Life Sci. 109(2) , 104-10, (2014)

Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-adminis...

[Rapid opiate detoxification under anesthesia (RODA)].

Rev. Med. Liege. 68(5-6) , 298-302, (2013)

Rapid Opiate Detoxification under Anesthesia (RODA) involves the use of opiate antagonists combined with anesthesia and pharmacotherapy to reduce withdrawal symptoms. The aim of our study was to measu...

[Blood-brain barrier transport of opioid analgesics].

Yakugaku Zasshi 131(10) , 1445-51, (2011)

Opioid analgesics exhibit cationic properties under physiological conditions, and the mechanism underlying permeation of the blood-brain barrier thus cannot be fully explained by simple diffusion alon...