GET73

GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

GET73 (1 µM, 10 µM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production[1]. Cell Viability Assay[1] Cell Line: Rat hippocampal neurons Concentration: 0.1 µM, 1 µM, 10 µM Incubation Time: 1 hour Result: Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.

GET73 (5–50 mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test[3]. Animal Model: Male SD rats (200-300 g and 300–350 g)[3] Dosage: 5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral gavage Result: Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.

[1]. Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35.

[2]. Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71.

[3]. Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.