M4076

Names

[ CAS No. ]:
2020089-41-0

[ Name ]:
M4076

Biological Activity

[Description]:

M4076 is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.M4076 sensitizes tumor cell lines to radiation therapy in vitro and strongly enhances the anti-tumor activity of ionizing radiation in vivo.

[References]

1. Stakyte K, et al. Nat Struct Mol Biol. 2021 Oct;28(10):789-798. 2. Thomas Fuchss, et al. Cancer Res (2019) 79 (13_Supplement): 3500.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁FN₆O₃

[ Molecular Weight ]:
448.458

Related Compounds

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