HsTX1

Names

[ CAS No. ]:
201948-00-7

[ Name ]:
HsTX1

Biological Activity

[Description]:

HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM inhibits TEM cell activation and attenuates inflammation in autoimmunity[1][2][3].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

Kv1.3:12 pM (IC50)

[References]

[1]. M Harunur Rashid, et al. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. 2014 Mar 28:4:4509. doi: 10.1038/srep04509.

[2]. Lebrun, Bruno, et al. A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. Biochemical Journal. 328 (Pt 1): 321–327.

[3]. Mark R. Tanner, et al. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Immunol. 2017 Jul; 180: 45–57. Published online 2017 Apr 4.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄₉H₂₄₆N₅₄O₄₆S₉

[ Molecular Weight ]:
3818.47

Related Compounds

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