201948-00-7

201948-00-7 structure

Name: HsTX1
Chemical Name: HsTX1
CAS Number: 201948-00-7
Molecular Formula: C₁₄₉H₂₄₆N₅₄O₄₆S₉
Molecular Weight: 3818.47
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2024-01-12 13:54:50
Modify Date: 2024-01-12 13:54:50
HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM inhibits TEM cell activation and attenuates inflammation in autoimmunity[1][2][3].

Name	HsTX1

Description	HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM inhibits TEM cell activation and attenuates inflammation in autoimmunity[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	Kv1.3:12 pM (IC50)
References	[1]. M Harunur Rashid, et al. A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. 2014 Mar 28:4:4509. doi: 10.1038/srep04509. [2]. Lebrun, Bruno, et al. A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. Biochemical Journal. 328 (Pt 1): 321–327. [3]. Mark R. Tanner, et al. Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog. Immunol. 2017 Jul; 180: 45–57. Published online 2017 Apr 4.

Molecular Formula	C₁₄₉H₂₄₆N₅₄O₄₆S₉
Molecular Weight	3818.47