N6-(2-Phenylethyl)adenosine
Names
[ CAS No. ]:
20125-39-7
[ Name ]:
N6-(2-Phenylethyl)adenosine
[Synonym ]:
2-(hydroxymethyl)-5-[6-(2-phenylethylamino)purin-9-yl]oxolane-3,4-diol
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.57g/cm3
[ Boiling Point ]:
723.5ºC at 760 mmHg
[ Molecular Formula ]:
C18H21N5O4
[ Molecular Weight ]:
371.39000
[ Flash Point ]:
391.3ºC
[ Exact Mass ]:
371.15900
[ PSA ]:
125.55000
[ LogP ]:
0.16540
[ Vapour Pressure ]:
5.72E-22mmHg at 25°C
[ Index of Refraction ]:
1.741
MSDS
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Nucleic Acids Res. 39 , 4373-86, (2011)
The carbon catabolite repressor protein 4 (Ccr4)-Negative on TATA (Not) complex controls gene expression at two levels. In the nucleus, it regulates the basal transcription machinery, nuclear receptor...
Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.Bioorg. Med. Chem. 12 , 2021-2034, (2004)
We synthesized phenyl ring-substituted analogues of N(6)-(1S,2R)-(2-phenyl-1-cyclopropyl)adenosine, which is highly potent in binding to the human A(3)AR with a Ki value of 0.63 nM. The effects of the...
Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice.Eur. J. Pharmacol. 371 , 137-145, (1999)
We have studied the effects of selective and non-selective adenosine receptor agonists and antagonists in audiogenic-seizure-sensitive DBA/2 mice, an animal model of generalized reflex epilepsy. With ...