Antitumor agent-71

Names

[ CAS No. ]:
2011756-99-1

[ Name ]:
Antitumor agent-71

Biological Activity

[Description]:

Antitumor Agent-71 is an antiproliferative activity antitumor agent and against tumor cell lines with IC50 values ranging from 3.98-15.70 μM. Antitumor Agent-71 is an antitumor agent that can inhibit tubulin polymerization.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

3.98/15.70/10.48/5.38 μM


[In Vitro]

Antitumor agent-71 (0.002-20 μM; 48 hours) inhibits the cell line HepG2, MCF-7, MIA PaCa-2, and Bel-7402 growth in a dose-dependent manner[1]. Cell Viability Assay Cell Line: HepG2, MCF-7, MIA PaCa-2, and Bel-7402[1]. Concentration: 0.002-20 μM Incubation Time: 48h Result: Showed antitumor activity against HepG2, MIA PaCa-2, MCF-7, and Bel-7402 cell lines with the IC50 values of 3.98/15.70/10.48/5.38 μM.

[In Vivo]

Antitumor agent-71 (10-20 mg/kg; intravenous injection; twice a day; 20 days) shows inhibitory effects and inhibits HepG2 cell line in nude mice[1]. Animal Model: HepG2 model BALB/c nude mice[1] Dosage: 10mg/kg, 20mg/kg Administration: Intravenous injection; twice a day; 20 days Result: Inhibited tumor growth in a dose-dependent manner.

[References]

[1]. Lianqi Sun, et al. Design, synthesis, and evaluations of the antiproliferative activity and aqueous solubility of novel carbazole sulfonamide derivatives as antitumor agents. Bioorg Chem. 2020 Jun;99:103766.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H31N5O4S

[ Molecular Weight ]:
509.62

Related Compounds