HER2-IN-2

Names

[ CAS No. ]:
2011708-43-1

[ Name ]:
HER2-IN-2

Biological Activity

[Description]:

HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases; equipotent to lapatinib against HER2 in vitro, also able to inhibit the small amount of HER3 auto-phosphorylation; inhibits 2YF/3TM gatekeeper mutant Ba/F3 cells lines with IC50 of 18.63 nM.

[References]

References 1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930. View Related Products by Target EGFR

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅N₅O₃

[ Molecular Weight ]:
373.372

Related Compounds

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