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epothilone E

Names

[ CAS No. ]:
201049-37-8

[ Name ]:
epothilone E

[Synonym ]:
4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione, 7,11-dihydroxy-3-[(E)-2-[2-(hydroxymethyl)-4-thiazolyl]-1-methylethenyl]-8,8,10,12-tetramethyl-, (1S,3S,7S,10R,11S,12S,16R)-
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-3-{(1E)-1-[2-(hydroxymethyl)-1,3-thiazol-4-yl]-1-propen-2-yl}-8,8,10,12-tetramethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Biological Activity

[Description]:

Epothilone E is a related compound of epothilone, which inhibits microtubule protein function and blocks cell division, and has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Susan Goodin, et al. Epothilones: mechanism of action and biologic activity. J Clin Oncol. 2004 May 15;22(10):2015-25.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
715.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H39NO7S

[ Molecular Weight ]:
509.65536

[ Flash Point ]:
386.5±32.9 °C

[ Exact Mass ]:
509.244720

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.543

Related Compounds