SB 243213 hydrochloride

Names

[ CAS No. ]:
200940-23-4

[ Name ]:
SB 243213 hydrochloride

[Synonym ]:
1H-Indole-1-carboxamide, 2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-, hydrochloride (1:2)
5-Methyl-N-{6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl}-6-(trifluoromethyl)-1-indolinecarboxamide dihydrochloride
Pazopanib + Tyverb/Tykerb

Biological Activity

[Description]:

SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1].

[Target]

5-HT2C Receptor:9.37 (pKi)

[In Vivo]

SB-243213 hydrochloride is a potent inhibitor of central 5-HT2C receptor-mediated function in rats. SB-243213 hydrochloride exhibits anxiolytic-like activity in both the social interaction and Geller-Seifter conflict tests[1].

[References]

[1]. Wood MD, et al. SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology. 2001 Aug;41(2):186-99.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₀ClF₃N₄O₂

[ Molecular Weight ]:
501.329

[ Exact Mass ]:
500.099365

[ PSA ]:
70.84000

[ LogP ]:
5.57770

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.