Nacubactam

Names

[ CAS No. ]:
2007923-17-1

[ Name ]:
Nacubactam

[Synonym ]:
1,6-Diazabicyclo[3.2.1]octane-2-carboxamide, N-(2-aminoethoxy)-7-oxo-6-(sulfooxy)-, (2S,5R)-, hydrate (1:1)
(2S,5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide hydrate (1:1)

Biological Activity

[Description]:

Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo. Bacterial Infection Phase 1 Clinical

[References]

References 1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86. 2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41. 3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60. 4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250. View Related Products by Target Bacterial Bacterial Infection

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₈N₄O₈S

[ Molecular Weight ]:
342.326

[ Exact Mass ]:
342.084534

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.