Uvarigrin

Names

[ CAS No. ]:
200563-11-7

[ Name ]:
Uvarigrin

[Synonym ]:
2(5H)-Furanone, 3-[(13S,15R)-13,15-dihydroxy-15-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]pentadecyl]-5-methyl-, (5S)-
(5S)-3-[(13S,15R)-13,15-Dihydroxy-15-{(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydro-2-furanyl}pentadecyl]-5-methyl-2(5H)-furanone

Biological Activity

[Description]:

Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Zhou GX, et al. Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata. J Nat Prod. 1999 Feb;62(2):261-4.

[2]. Li YF, et al. Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism. Yao Xue Xue Bao. 2006 Mar;41(3):252-6.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
741.3±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₇H₆₈O₆

[ Molecular Weight ]:
608.932

[ Flash Point ]:
218.0±19.4 °C

[ Exact Mass ]:
608.501587

[ LogP ]:
9.91

[ Vapour Pressure ]:
0.0±5.6 mmHg at 25°C

[ Index of Refraction ]:
1.497

Uvarigrin

Names

Biological Activity

Chemical & Physical Properties

Related Compounds