200563-11-7

200563-11-7 structure

Name: Uvarigrin
Chemical Name: (5S)-3-[(13S,15R)-13,15-Dihydroxy-15-{(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydro-2-furanyl}pentadecyl]-5-methyl-2(5H)-furanone
CAS Number: 200563-11-7
Molecular Formula: C₃₇H₆₈O₆
Molecular Weight: 608.932
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-23 11:04:57
Modify Date: 2025-08-25 06:38:58
Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation[1][2].

Name	(5S)-3-[(13S,15R)-13,15-Dihydroxy-15-{(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydro-2-furanyl}pentadecyl]-5-methyl-2(5H)-furanone
Synonyms	2(5H)-Furanone, 3-[(13S,15R)-13,15-dihydroxy-15-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]pentadecyl]-5-methyl-, (5S)- (5S)-3-[(13S,15R)-13,15-Dihydroxy-15-{(2R,5R)-5-[(1R)-1-hydroxytridecyl]tetrahydro-2-furanyl}pentadecyl]-5-methyl-2(5H)-furanone

Description	Uvarigrin, isolated from the roots of Uvaria calamistrata, induces tumor multidrug resistance cell apoptosis and triggers Caspase-9 activation[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Zhou GX, et al. Calamistrins A and B, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Uvaria calamistrata. J Nat Prod. 1999 Feb;62(2):261-4. [2]. Li YF, et al. Induction of apoptosis of tumor multidrug resistance cell by uvarigrin and its mechanism. Yao Xue Xue Bao. 2006 Mar;41(3):252-6.