eCF-309

Names

[ CAS No. ]:
2001571-40-8

[ Name ]:
eCF-309

[Synonym ]:
2-Benzoxazolamine, 5-[4-amino-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-
3-(2-Amino-1,3-benzoxazol-5-yl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

[Description]:

eCF309 is a potent and highly selective mTOR inhibitor with remarkably low off-target activities (IC50 = 10-15 nM, both in vitro and in cells)[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

[References]

[1]. Craig Fraser, et al. eCF309: a potent, selective and cell-permeable mTOR inhibitor. Med. Chem. Commun., 2016, 7, 471-477.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
642.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₁N₇O₃

[ Molecular Weight ]:
383.404

[ Flash Point ]:
342.4±34.3 °C

[ Exact Mass ]:
383.170593

[ LogP ]:
2.31

[ Appearance of Characters ]:
solid

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.727

[ Storage condition ]:
Store at -20℃

[ Water Solubility ]:
Soluble in DMSO

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.